A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease
Identifieur interne : 000C18 ( Main/Exploration ); précédent : 000C17; suivant : 000C19A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease
Auteurs : Valerie Voon [États-Unis] ; Paul Krack [États-Unis] ; Anthony E. Lang [États-Unis] ; Andres M. Lozano [États-Unis] ; Kathy Dujardin [États-Unis] ; Michael Schüpbach [États-Unis] ; James D Mbrosia [États-Unis] ; Stephane Thobois [États-Unis] ; Filippo Tamma [États-Unis] ; Jan Herzog [États-Unis] ; Johannes D. Speelman [États-Unis] ; Johan Samanta [États-Unis] ; Cynthia Kubu [États-Unis] ; Helene Rossignol [États-Unis] ; Yu-Yan Poon [États-Unis] ; Jean A. Saint-Cyr [États-Unis] ; Claire Ardouin [États-Unis] ; Elena Moro [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2008-10.
Abstract
Subthalamic nucleus deep brain stimulation improves motor symptoms and quality of life in advanced Parkinson's disease. As after other life-altering surgeries, suicides have been reported following deep brain stimulation for movement disorders. We sought to determine the suicide rate following subthalamic nucleus deep brain stimulation for Parkinson's disease by conducting an international multicentre retrospective survey of movement disorder and surgical centres. We further sought to determine factors associated with suicide attempts through a nested case-control study. In the survey of suicide rate, 55/75 centres participated. The completed suicide percentage was 0.45% (24/5311) and attempted suicide percentage was 0.90% (48/5311). Observed suicide rates in the first postoperative year (263/100 000/year) (0.26%) were higher than the lowest and the highest expected age-, gender- and country-adjusted World Health Organization suicide rates (Standardized Mortality Ratio for suicide: SMR 12.63–15.64; P < 0.001) and remained elevated at the fourth postoperative year (38/100 000/year) (0.04%) (SMR 1.81–2.31; P < 0.05). The excess number of deaths was 13 for the first postoperative year and one for the fourth postoperative year. In the case-control study of associated factors, 10 centres participated. Twenty-seven attempted suicides and nine completed suicides were compared with 70 controls. Postoperative depression (P < 0.001), being single (P = 0.007) and a previous history of impulse control disorders or compulsive medication use (P = 0.005) were independent associated factors accounting for 51% of the variance for attempted suicide risk. Attempted suicides were also associated (P < 0.05) with being younger, younger Parkinson's disease onset and a previous suicide attempt. Completed suicides were associated with postoperative depression (P < 0.001). Postoperative depression remained a significant factor associated with attempted and completed suicides after correction for multiple comparisons using the stringent Bonferroni correction. Mortality in the first year following subthalamic nucleus deep brain stimulation has been reported at 0.4%. Suicide is thus one of the most important potentially preventable risks for mortality following subthalamic nucleus deep brain stimulation for Parkinson's disease. Postoperative depression should be carefully assessed and treated. A multidisciplinary assessment and follow-up is recommended.
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DOI: 10.1093/brain/awn214
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Lang</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="D Mbrosia, James" sort="D Mbrosia, James" uniqKey="D Mbrosia J" first="James" last="D Mbrosia">James D Mbrosia</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stephane" last="Thobois">Stephane Thobois</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Tamma, Filippo" sort="Tamma, Filippo" uniqKey="Tamma F" first="Filippo" last="Tamma">Filippo Tamma</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Samanta, Johan" sort="Samanta, Johan" uniqKey="Samanta J" first="Johan" last="Samanta">Johan Samanta</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Kubu, Cynthia" sort="Kubu, Cynthia" uniqKey="Kubu C" first="Cynthia" last="Kubu">Cynthia Kubu</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rossignol, Helene" sort="Rossignol, Helene" uniqKey="Rossignol H" first="Helene" last="Rossignol">Helene Rossignol</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, University of Toronto, UHN, Toronto, ON, Canada, University Joseph Fourier, Grenoble, Lille University Hospital, Lille, National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France, Neurological clinic, Ospedale San Paolo, Italy, Christian-Albrechts-Universität Kiel, Kiel, Germany, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands, University of Arizona, Phoenix, AR and The Cleveland Clinic Foundation, OH</wicri:regionArea><placeName><region type="state">Ohio</region><settlement type="city">Toronto</settlement></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">131</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="2720">2720</biblScope><biblScope unit="page" to="2728">2728</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">0577379963CD9979BC61E2892F2712FE5EE18535</idno><idno type="DOI">10.1093/brain/awn214</idno><idno type="ArticleID">awn214</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Subthalamic nucleus deep brain stimulation improves motor symptoms and quality of life in advanced Parkinson's disease. As after other life-altering surgeries, suicides have been reported following deep brain stimulation for movement disorders. We sought to determine the suicide rate following subthalamic nucleus deep brain stimulation for Parkinson's disease by conducting an international multicentre retrospective survey of movement disorder and surgical centres. We further sought to determine factors associated with suicide attempts through a nested case-control study. In the survey of suicide rate, 55/75 centres participated. The completed suicide percentage was 0.45% (24/5311) and attempted suicide percentage was 0.90% (48/5311). Observed suicide rates in the first postoperative year (263/100 000/year) (0.26%) were higher than the lowest and the highest expected age-, gender- and country-adjusted World Health Organization suicide rates (Standardized Mortality Ratio for suicide: SMR 12.63–15.64; P < 0.001) and remained elevated at the fourth postoperative year (38/100 000/year) (0.04%) (SMR 1.81–2.31; P < 0.05). The excess number of deaths was 13 for the first postoperative year and one for the fourth postoperative year. In the case-control study of associated factors, 10 centres participated. Twenty-seven attempted suicides and nine completed suicides were compared with 70 controls. Postoperative depression (P < 0.001), being single (P = 0.007) and a previous history of impulse control disorders or compulsive medication use (P = 0.005) were independent associated factors accounting for 51% of the variance for attempted suicide risk. Attempted suicides were also associated (P < 0.05) with being younger, younger Parkinson's disease onset and a previous suicide attempt. Completed suicides were associated with postoperative depression (P < 0.001). Postoperative depression remained a significant factor associated with attempted and completed suicides after correction for multiple comparisons using the stringent Bonferroni correction. Mortality in the first year following subthalamic nucleus deep brain stimulation has been reported at 0.4%. Suicide is thus one of the most important potentially preventable risks for mortality following subthalamic nucleus deep brain stimulation for Parkinson's disease. Postoperative depression should be carefully assessed and treated. A multidisciplinary assessment and follow-up is recommended.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name></region><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name><name sortKey="D Mbrosia, James" sort="D Mbrosia, James" uniqKey="D Mbrosia J" first="James" last="D Mbrosia">James D Mbrosia</name><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><name sortKey="Kubu, Cynthia" sort="Kubu, Cynthia" uniqKey="Kubu C" first="Cynthia" last="Kubu">Cynthia Kubu</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><name sortKey="Rossignol, Helene" sort="Rossignol, Helene" uniqKey="Rossignol H" first="Helene" last="Rossignol">Helene Rossignol</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Samanta, Johan" sort="Samanta, Johan" uniqKey="Samanta J" first="Johan" last="Samanta">Johan Samanta</name><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><name sortKey="Tamma, Filippo" sort="Tamma, Filippo" uniqKey="Tamma F" first="Filippo" last="Tamma">Filippo Tamma</name><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stephane" last="Thobois">Stephane Thobois</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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